I've always been a big fan of taking old songs and completely turning them on their head. Having no adherence to the fine tradition of the original version. Rearranging them and taking a different approach to them.
I don't think there's any music that you hear on the radio today that would be possible without Jimi Hendrix. Rock, blues-rock, heavy metal, any guitar stuff when you get right down to it - Jimi did it. He's certainly the guy who basically invented the blues-rock genre for guitar players.
That's where the Black Keys and Jack White have succeeded and I've failed: They've actually convinced college kids that they're listening to hip music - but it's just blues twisted a new way - while I'm playing for the college kid's parents.
If you have a good riff with a vocal as well, then it becomes a devastating song. That's why people love riff-rock: it's the ultimate air guitar music.