Preconceived ideas are like searchlights which illumine the path of the experimenter and serve him as a guide to interrogate nature. They become a danger only if he transforms them into fixed ideas-this is why I should like to see these profound words inscribed on the threshold of all the temples of science: 'The greatest derangement of the mind is to believe in something because one wishes it to be so.'

Imagination should give wings to our thoughts but we always need decisive experimental proof, and when the moment comes to draw conclusions and to interpret the gathered observations, imagination must be checked and documented by the factual results of the experiment.

Virulence appears in a new light which cannot but be alarming to humanity; unless nature, in her evolution down the ages (an evolution which, as we now know, has been going on for millions, nay, hundreds of millions of years), has finally exhausted all the possibilities of producing virulent or contagious diseases - which does not seem very likely.

To demonstrate experimentally that a microscopic organism actually is the cause of a disease and the agent of contagion, I know no other way, in the present state of Science, than to subject the microbe (the new and happy term introduced by M. Sédillot) to the method of cultivation out of the body.

There are two men in each one of us: the scientist, he who starts with a clear field and desires to rise to the knowledge of Nature through observations, experimentation and reasoning, and the man of sentiment, the man of belief, the man who mourns his dead children, and who cannot, alas, prove that he will see them again, but who believes that he will, and lives in the hope – the man who will not die like a vibrio, but who feels that the force that is within him cannot die.

These microscopic organisms form an entire world composed of species, families and varieties whose history, which has barely begun to be written, is already fertile in prospects and findings of the highest importance. The names of these organisms are very numerous and will have to be defined and in part discarded. The word microbe which has the advantage of being shorter and carrying a more general meaning, and of having been approved by my illustrious friend, M. Littré, the most competent linguist in France, is one we will adopt.

Without theory, practice is but routine born of habit. Theory alone can bring forth and develop the spirit of invention. ... [Do not] share the opinion of those narrow minds who disdain everything in science which has not an immediate application. ... A theoretical discovery has but the merit of its existence: it awakens hope, and that is all. But let it be cultivated, let it grow, and you will see what it will become.

After death, life reappears in a different form and with different laws. It is inscribed in the laws of the permanence of life on the surface of the earth and everything that has been a plant and an animal will be destroyed and transformed into a gaseous, volatile and mineral substance.

The universe is an asymmetrical entity. I am inclined to believe that life as it is manifested to us must be a function of the asymmetry of the universe or of the consequence of this fact. The universe is asymmetrical; for if one placed the entire set of bodies that compose the solar system, each moving in its own way, before a mirror, the image shown would not be superimposable on the reality.

My opinion - nay more, my conviction - is that, in the present state of science, as you rightly say, spontaneous generation is a chimera; and it would be impossible for you to contradict me, for my experiments all stand forth to prove that spontaneous generation is a chimera.

We affirm the neutrality of Science ... Science is of no country. ... But if Science has no country, the scientist must keep in mind all that may work towards the glory of his country. In every great scientist will be found a great patriot.

No, there is now no circumstance known in which it can be affirmed that microscopic beings came into the world without germs, without parents similar to themselves. Those who affirm it have been duped by illusions, by ill-conducted experiments, spoilt by errors that they either did not perceive or did not know how to avoid.

I propose to provide proof... that just as always an alcoholic ferment, the yeast of beer, is found where sugar is converted into alcohol and carbonic acid, so always a special ferment, a lactic yeast, is found where sugar is transformed into lactic acid. And, furthermore, when any plastic nitrogenated substance is able to transform sugar into that acid, the reason is that it is a suitable nutrient for the growth of the [lactic] ferment.

Great problems are now being handled, keeping every thinking man in suspense; the unity or multiplicity of human races; the creation of man 1,000 years or 1,000 centuries ago; the fixity of species, or the slow and progressive transformation of one species into another; the eternity of matter; the idea of a God unnecessary: such are some of the questions that humanity discusses nowadays.

Are the atoms of the dextroacid (tartaric) grouped in the spirals of a right-hand helix or situated at the angles of an irregular tetrahedron, or arranged in such or such particular unsymmetrical fashion? We are unable to reply to these questions. But there can be no reason for doubting that the grouping of the atoms has an unsymmetrical arrangement with a non-superimposable image. It is not less certain that the atoms of the laevo-acid realize precisely an unsymmetrical arrangement of the inverse of the above.

You bring me the deepest joy that can be felt by a man whose invincible belief is that Science and Peace will triumph over Ignorance and War, that nations will unite, not to destroy, but to build, and that the future will belong to those who will have done most for suffering humanity.

In that memorable year, 1822: Oersted, a Danish physicist, held in his hands a piece of copper wire, joined by its extremities to the two poles of a Volta pile. On his table was a magnetized needle on its pivot, and he suddenly saw (by chance you will say, but chance only favours the mind which is prepared) the needle move and take up a position quite different from the one assigned to it by terrestrial magnetism. A wire carrying an electric current deviates a magnetized needle from its position. That, gentlemen, was the birth of the modern telegraph.

Herrmann Pidoux and Armand Trousseau stated 'Disease exists within us, because of us, and through us', Pasteur did not entirely disagree, 'This is true for certain diseases', he wrote cautiously, only to add immediately: 'I do not think that it is true for all of them'.

Every chemical substance, whether natural or artificial, falls into one of two major categories, according to the spatial characteristic of its form. The distinction is between those substances that have a plane of symmetry and those that do not. The former belong to the mineral, the latter to the living world.