I never thought I'd end up living in Los Angeles while my children grew up in Britain, but here I am, and we are all making the best of it.

The strange thing - and this is one of the advantages of being incredibly shallow and superficial - is that wherever I am, that's sort of home.

The first big stars, Bessie Smith, Ma Rainey, you know, these were gigantic stars. I even wonder sometimes whether all music actually comes from women, whether the first glimmering of music is a mother soothing a baby.

Even the greatest poets, I think, cannot quite get to the places that music can get to in the human - I was gonna say mind, but it's actually the entire body. It somehow seems to infuse the entire body.

Muddy Waters, I suppose, was my first great hero. You know, every boy wants to be a guitar player, and Muddy Waters was just the king. He was the King Bee. He was it.

I have always stuck up for Western medicine. You can chew all the celery you want, but without antibiotics, three quarters of us would not be here.

The financing of all TV shows is dictated by finding an audience between 18 and 49. I have now passed beyond 49, so probably, I am no longer a desirable commodity for TV. And I am at peace with that; that's fine.

In film, because you know where the ending is, characters can change, but in television, you substitute revelation for change, and that can be hard to pull off.

Girls are complicated. The instruction manual that comes with girls is 800 pages, with chapters 14, 19, 26 and 32 missing, and it's badly translated, hard to figure out.

L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally.

One of the principal goals in my life has been to avoid embarrassing my children by doing the job I do. I hope I've managed to do that, and I hope that, with the job I'm in now, they are, if not proud, at least unembarrassed by it. I must say, my three are most agreeable children, who do nothing but delight me.

Humility was considered a great virtue in my family household. No show of complacency or self-satisfaction was ever tolerated. Patting yourself on the back was definitely not encouraged, and pleasure or pride would be punishable by death.

Music is one of the noblest callings I can think of. It's the highest of all the art forms to me. For example, if my kid said to me, 'I want to give it all up,' whatever it is that they're doing, 'and I want to take my saxophone and go out,' I would say, 'May God go with you. This is a great and noble thing that you're doing.'

Celebrity is absolutely preposterous. Entertainment seems to be inflating. It used to be the punctuation to your life, a film or a novel or a play, a way of celebrating a good week or month. Now it feels as if it's all punctuation.

I personally believe that the iPod is a frankly corrosive device because it encourages you to surround yourself with your favorites. The whole idea of a playlist is to surround yourself with your favorite things, and the interesting thing is that when you do that, they cease to be your favorites.

I don't really understand why everybody doesn't want to direct. It's an absolutely fascinating combination of skills required and puzzles set on every possible level, emotional and practical and technical. It calls upon such a wide variety of skills. I find it completely absorbing.

The great trap for non-American actors trying to play Americans, I think, is to start thinking of American-ness as a characteristic. It isn't. It is no more a character trait than height. It is just a physical fact, and that's all there is to it.

Clive Dunn, as I understand it, retired to the south of Spain, where he worked extensively in watercolours. I don't own any of Clive Dunn's watercolours. I loved him in 'Dad's Army,' loved him. But not enough to actually seek out his watercolour work.

I never went to drama school, I don't have any certificates saying: 'He's a qualified actor.' But I did think that 'House' was something I didn't have to apologise for. It was something I was really proud of and it was sort of... whether you liked it or not, it was undeniable.

Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.

As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we?

Riding my motorcycle around L.A. is like my own video game. But unlike many folks at the wheel, I am occupied with getting where I'm going and keeping myself safe. Most people are applying makeup, texting, and checking out the beauty in the next car.

I'm reasonably easygoing. Messing up my lines or making a fool of myself is where you find my fears. Like a lot of English people, I'm prey to embarrassment - the dread that everyone's sort of sniggering at you, that you're going to look like an idiot. I think that sort of halts us all.

I think pain is a very - it's an extremely hard thing to empathize moment to moment. And you often don't remember your own pain, you know, that moment that you broke a limb or you burned yourself or, I think, this is a common thing that women talk about with childbirth, that the memory of the pain is hard to summon up and relive, thankfully.

Ideas are 10 a penny. It's the execution that's the hard thing to do. House is standing up against a tide of sentiment and emotionalism over reason that threatens to engulf this world. When you think about it, a rationalist, a man of science and reason, is in a pretty lonely position.

I think of House as a deeply moral character, though some would no doubt argue with me. He does not judge. Beyond his normal tetchiness, there were no more than a half-dozen moments of actual condemnation from him. He understood lies and also why you lied, and there was an absolution there that is very, very appealing.

I get anxious about a lot of things, that's the trouble. I get anxious about everything. I just can't stop thinking about things all the time. And here's the really destructive part - it's always retrospective. I waste time thinking of what I should have said or done.

I feel like a hostage to fortune. Not that I am complaining. I wanted to play the role. But in truth I didn't think the show would be such a success. OK, I thought it would fail. Not because it was bad. I was confident it was good, but plenty of good things just sort of wither on the vine.

I grew up with an impatience with the anti-scientific. So I'm a bit miffed with our current love affair with all things Eastern. If I sneeze on the set, 40 people hand me echinacea. But I'd no sooner take that than eat a pencil. Maybe that's why I took up boxing. It's my response to men in white pajamas feeling each other's chi.