The Premier League is what it is. Some people will see the intensity and quality as a great advantage for your players: it will make them better. Some will see it as a disadvantage because the players play at such a high level and such intensity, it's difficult for them to drum that up, that intensity, with a very short space of rest time.
It's true that if it's always going to be that if you win the World Cup or European Championship, you're a success, and if you don't, you're a failure, then you're bedding yourself for a lack of success because there aren't many coaches who have won those things, and there are thousands who haven't.