It does not feel any different being directed by a first-timer as long as I am convinced that the director is passionate about the film he or she is making. If you get a sense of their vision for the film and their aesthetics of your performance, then it does not matter whether you work with a new or an experienced director.
I have been a fan of movies from a very young age, and somehow, the magic of that - every single time I hear something or read something that could be made into a wonderful film or something somebody is asking me to be a part of - that connects. It just makes me feel like I'm going to be part of something magical again.