At the most fundamental level, it is an honor to serve - at whatever type or size of organization you are privileged to lead, whether it is a for-profit or nonprofit. It is an honor to serve. Starting from that foundation, it is important to have a compelling vision and a comprehensive plan.
The reason I loved working at Boeing was because I loved the idea of air travel as a way of bringing people and cultures together - because when we come together as people and cultures, we realize that we are not that different after all, and when we realize that we are not that different after all, the world becomes a better place.